VirtualBox Wrapper
Wrapper to provide easy to use GUI isolation[1].
Xinput and clipboard isolation
VirtualBox offers some protections agains inherent insecurities on X server architecture[2] but not as tough as Qubes or maybe how Subgraph is planning.
It's still possible to sandbox applications using VirtualBox and have some level of protection while having a slightly simple setup if you can't migrate to Qubes:
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Clipboard sharing: you can entirelly disable this feature or have just the hability to copy content from the VM to the host X session.
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Xinput isolation: by my early testings, VirtualBox provides xinput isolation as the guest can just capture events when the guest window is focused. But this needs further research.
References: